Yes, there is something like levels of caffeine sensitivity depending on how your body responds to it.
A regular cup of coffee –filtered, espresso or instant coffee– contains something like 75mg to 100mg of caffeine. After drinking coffee, caffeine is absorbed in your stomach and intestines and goes into the bloodstream. The stimulating effect of caffeine is associated with A1 and A2A adenosine receptors in your brain.
The effects of caffeine can last many hours depending on how fast it is metabolized and broken down in the liver and flushed out via urine.
People with high sensitivity to caffeine have a slow metabolism in the liver and high binding in the central nervous system –this means that even small amounts of caffeine will have a stimulating effect, and higher doses can lead o sleep issues.
People who have a regular sensitivity to caffeine can drink anywhere between 2 and 5 cups of coffee a day without any adverse reactions.
And those with low sensitivity to caffeine metabolize the substance quickly in the liver and are not affected by coffee.
You may also like this article!